Treatment with boosted protease inhibitors (PIs) works in HIV 1 group O.

Forty-seven HIV 1 type O infected treatment naïve individuals in
Cameroon were included in a study where treatment was given
with a combination of 2 NRTIs and a boosted PI. For each participant,
2 matched controls with HIV group M were included
receiving the same treatment. After 48 weeks of treatment there
was no significant difference in the proportion with undetectable
virus between the patients with HIV 1 group O and group M.

Ref; Kouanfack et al. Clin Infect Dis. 2019 May 7. pii: ciz371. doi: 10.1093/cid/
ciz371[Epub ahead of print]

Comment: HIV type O is exceedingly rare and very few
cases have been found outside Cameroon where it is also rare.
Nevertheless, in the very unlikely event that one would care
for a patient with type O it is good to know that a standard
combination of a PI and 2 nucleosides will probably work.